15 Animes Similar to Cybersix You’ll Definitely Love

Cybersix (1999) follows a female gynoid living a double life: by day, she poses as male teacher Adrian Seidelman, and by night, she battles her creator Dr. Von Reichter in a dystopian city. The series blends cyberpunk aesthetics, genetic engineering, secret identities, and themes of humanity amid mechanization. Despite its cult status, many anime with similar DNA remain overlooked.

Below are 15 underrated series that echo Cybersix’s core elements—double lives, biopunk/cyberpunk worlds, strong female leads, and unique visual styles—deserving wider recognition.

1. Armitage III: Poly-Matrix (1995)

• Streaming: Crunchyroll
• Episodes: 4 OVAs
• Plot: On Mars, detective Ross Sylibus partners with android Armitage to investigate murders targeting “Third Types” (advanced androids). Their probe uncovers a conspiracy threatening human-android coexistence.
• Similarities: Like Cybersix, Armitage hides her synthetic nature while fighting systemic corruption. Both explore identity crises within oppressive societies, blending noir and cyberpunk.

2. Genocyber (1994)

• Streaming: RetroCrush
• Episodes: 5 OVAs
• Plot: Psychic sisters Elaine and Diana merge into the bio-weapon “Genocyber,” unleashed by corporations in a war-torn future. Their bond becomes humanity’s last hope against militarized chaos.
• Similarities: Cybersix’s genetic engineering themes mirror Genocyber’s body-horror biopunk. Both feature female protagonists weaponized by creators, fighting for autonomy amid grotesque experimentation.

3. Wicked City (1987)

• Streaming: Amazon Prime Video
• Episodes: Film
• Plot: Agents Taki and Makie must secure a peace treaty between humans and demons, navigating interdimensional betrayals and body-snatching horrors.
• Similarities: Shares Cybersix’s dark urban fantasy, leather-clad heroines, and morally gray battles. Both use eroticism and visceral action to critique societal decay.

4. Black Magic M-66 (1987)

• Streaming: RetroCrush
• Episodes: 1 OVA
• Plot: Journalist Sybel uncovers military androids targeting a scientist’s granddaughter, leading to a chase through a neon-drenched metropolis.
• Similarities: Cybersix’s man-vs-creator conflict parallels M-66’s rogue AI narrative. Both feature resilient women confronting mechanized threats in claustrophobic cityscapes.

5. Texhnolyze (2003)

• Streaming: Crunchyroll
• Episodes: 22
• Plot: In the underground city Lux, amputee Ichise gains cybernetic limbs and becomes embroiled in gang wars, existential collapse, and techno-spiritual dread.
• Similarities: Echoes Cybersix’s bio-augmentation themes and dystopian nihilism. Its bleak visual storytelling mirrors Adrian’s struggle for purpose.

6. Angel Cop (1989)

• Streaming: RetroCrush
• Episodes: 6 OVAs
• Plot: Counterterrorism agent Angel battles psychic terrorists and government conspiracies in a near-future Tokyo.
• Similarities: Cybersix’s vigilante justice aligns with Angel’s ruthless idealism. Both critique authoritarianism through hyper-violent, politically charged narratives.

7. Megazone 23 (1985)

• Streaming: RetroCrush
• Episodes: 4 OVAs
• Plot: Biker Shogo Yahagi discovers his city is a simulation aboard a spaceship, fleeing authorities to expose the truth.
• Similarities: Like Adrian’s double life, Shogo hides from omnipotent systems. Both use noir aesthetics to dissect reality vs. illusion.

8. Claymore (2007)

• Streaming: Netflix, Hulu
• Episodes: 26
• Plot: Clare, a half-human warrior, hunts shape-shifting demons while seeking vengeance against those who created her kind.
• Similarities: Cybersix’s creator-antagonist dynamic mirrors Clare’s quest. Both subvert “monstrous femininity” tropes, emphasizing sisterhood and defiance.

9. Moribito: Guardian of the Spirit (2007)

• Streaming: Crunchyroll
• Episodes: 26
• Plot: Spear-wielding mercenary Balsa protects a prince possessed by a water spirit, evading assassins across a mythic empire.
• Similarities: Balsa’s protector role and moral complexity reflect Cybersix’s heroic duality. Both blend fantasy with grounded character studies.

10. Serial Experiments Lain (1998)

• Streaming: Funimation
• Episodes: 13
• Plot: Teen Lain Iwakura navigates the virtual realm “The Wired,” unraveling conspiracies that blur her identity and reality.
• Similarities: Cybersix’s identity crisis finds a digital counterpart in Lain. Both use surreal visuals to explore humanity in tech-dominated worlds.

11. Ergo Proxy (2006)

• Streaming: Hulu
• Episodes: 23
• Plot: Inspector Re-l Mayer investigates sentient androids in a domed city, uncovering government secrets linked to her own existence.
• Similarities: Re-l’s gothic cyberpunk journey parallels Cybersix’s battle against creators. Both feature androids questioning free will amid decay.

12. The Big O (1999)

• Streaming: Crunchyroll
• Episodes: 26
• Plot: Negotiator Roger Smith pilots a giant mech in Paradigm City, where amnesiac citizens confront fragments of a buried past.
• Similarities: Shares Cybersix’s noir tone, amnesiac heroes, and city-as-prison metaphor. Both blend pulp action with philosophical depth.

13. Michiko & Hatchin (2008)

• Streaming: Crunchyroll
• Episodes: 22
• Plot: Escaped convict Michiko rescues abused girl Hatchin, journeying across South America to find Hatchin’s father.
• Similarities: Cybersix’s found-family dynamic resonates here. Both use vibrant art to frame female resilience against systemic oppression.

14. Noir (2001)

• Streaming: HIDIVE
• Episodes: 26
• Plot: Amnesiac assassin Mireille partners with Kirika to unravel their connection to the ancient assassin guild “Noir”.
• Similarities: Mirrors Cybersix’s secret-society conflicts and stylish action. Both protagonists reclaim agency through violent, shadowy pasts.

15. Kite (1998)

• Streaming: Amazon Prime Video
• Episodes: Film
• Plot: Teen assassin Sawa avenges her parents’ death, manipulated by corrupt cops in a crime-ridden metropolis.
• Similarities: Cybersix’s vigilante justice aligns with Sawa’s brutal quest. Both critique exploitation through unflinching, adult-oriented narratives.

Why These Anime Resonate with Cybersix Fans

These series share Cybersix’s DNA through:

• Double Lives: Protagonists like Armitage and Re-l conceal identities while battling systemic corruption.
• Bio/Cyberpunk Aesthetics: Genocyber and Texhnolyze mirror Cybersix’s body horror and dystopian cities.
• Female Agency: Claymore’s Clare and Michiko & Hatchin’s leads defy exploitation, echoing Adrian’s resilience.
• Visual Innovation: Angel Cop’s political grit and Lain’s digital surrealism offer distinct yet thematically aligned styles.

Despite limited mainstream traction, these titles deliver the moral complexity, inventive worlds, and fierce heroines that define Cybersix’s legacy. Their underrated status makes them essential deep cuts for fans seeking kindred narratives.