The Sylvester & Tweety Mysteries (1995-2002) follows Warner Bros.’ eternally feuding cat-and-bird duo as they join Granny on globe-trotting whodunits that blend slap-stick, detective logic and constant role-reversals1. At its heart lie three evergreen hooks: a playful “power system” of cartoon physics, the underdog charm of a hapless cat who never quits, and nonstop subversion of viewer expectations.
The 15 series below echo those hooks—mystery-driven plots, odd-couple dynamics, trickster humour or inventive rule-sets—yet rarely get the spotlight they deserve. Each title mixes older gems with recent sleepers, proving there is still plenty of clever, character-led sleuthing beyond the mainstream.
1. Sherlock Hound (1984)

- Streaming: YouTube (official), Amazon Prime
- MAL Score / Episodes: 7.3 / 26
- Studio | Staff: TMS Entertainment; six episodes directed by Hayao Miyazaki
- Plot (2 sent.): Canine versions of Holmes & Watson foil Moriarty’s capers in steam-age London. Air-ships, gadgets and dry wit keep cases breezy.
- Similarities: Slap-stick detective work, wild tech “power gimmicks,” and a predator–prey chase that always resets without hard feelings.
2. The Mythical Detective Loki Ragnarok (2003)

- Streaming: HIDIVE
- MAL Score / Episodes: 7.0 / 26
- Studio | Staff: Studio DEEN; dir. Hiroshi Watanabe
- Plot: Norse god Loki, exiled as a child, runs a modern occult agency with a hyper-curious girl.
- Similarities: Oppositional duo, mystery-of-the-week format and constant rug-pulls on who really holds the power.
3. Detective Academy Q (2003)

- Streaming: Crunchyroll (sub)
- MAL Score / Episodes: 7.9 / 45
- Studio | Staff: Pierrot; music by Akira Senju
- Awards: 48th Shogakukan Manga Award (source manga)
- Plot: Five trainees unravel murders while vying to join the elite DDS agency.
- Similarities: Underdog students out-smart seasoned criminals; self-contained clues mirror Tweety’s sudden “aha!” moments.
4. UN-GO (2011)

- Streaming: Crunchyroll, HIDIVE
- MAL Score / Episodes: 7.4 / 11 + film
- Studio | Staff: Bones; chief director Seiji Mizushima
- Plot: A down-on-his-luck detective and his shapeshifting partner expose state cover-ups in post-war Tokyo.
- Similarities: Odd pair banter, revelations that flip every case’s premise, and a running gag of the hero being out-matched by his smaller partner.
5. Hamatora: The Animation (2014)

- Streaming: Crunchyroll
- MAL Score / Episodes: 7.1 / 12 + S2
- Studio | Staff: NAZ × Lerche; character design Yū Watanabe
- Plot: Café-lounging gumshoes wield “Minimum” super-abilities while chasing a serial killer.
- Similarities: Flashy rule-bound powers, team misfits, and comic timing that interrupts tense mysteries.
6. The Kubikiri Cycle (OVA 2016)

- Streaming: Crunchyroll
- MAL Score / Episodes: 7.8 / 8
- Studio | Staff: Shaft; based on NISIOISIN novel
- Plot: An island retreat for geniuses turns lethal after a locked-room beheading.
- Similarities: Clue-hunting with constant red herrings; every episode tweaks audience expectations of “who’s hunting whom.”
7. Trickster (2016)

- Streaming: Crunchyroll, Funimation
- MAL Score / Episodes: 6.3 / 24
- Studio | Staff: TMS × Shin-Ei; story inspired by Edogawa Ranpo
- Plot: An immortal teen joins a boys’ detective club led by a wheelchair-bound prodigy.
- Similarities: Cat-and-mouse interplay, slap-stick injuries that never stick, and stylish gadgetry as a “power system.”
8. Double Decker! Doug & Kirill (2018)

- Streaming: Crunchyroll, Funimation
- MAL Score / Episodes: 7.5 / 13 + EXs
- Studio | Staff: Sunrise; chief director Joji Furumoto
- Plot: A jaded veteran and a clueless rookie battle “Anthem” drug mutants in a buddy-cop romp.
- Similarities: Bickering partners, episodic crimes, and comic narration that winks at its own clichés—very Sylvester-esque.
9. B: The Beginning (2018)

- Streaming: Netflix global
- MAL Score / Episodes: 7.2 / 18 + S2
- Studio | Staff: Production I.G; creator Kazuto Nakao
- Plot: A genius detective chases a vigilante with super-human “wings” amid corporate conspiracies.
- Similarities: Violent take on predator-vs-prey hunts and rule-bending powers that upset each investigation.
10. Case File nº221: Kabukicho (2019)

- Streaming: Funimation, Crunchyroll
- MAL Score / Episodes: 6.5 / 24
- Studio | Staff: Production I.G; script Taku Kishimoto
- Plot: A neon-soaked East-End London hosts six eccentric detectives competing for cases.
- Similarities: Ensemble comedy, episodic mysteries, and constant one-upmanship reminiscent of Tweety’s smug reveals.
11. ID: Invaded (2020)

- Streaming: Funimation, Hulu
- MAL Score / Episodes: 7.6 / 13
- Studio | Staff: NAZ; original creator Ōtarō Maijō
- Plot: Investigators dive into criminals’ subconscious “id-wells” to solve murders.
- Similarities: Formalised power system (Mizuhanome tech) and a hero who blunders into clues like Sylvester’s accidental discoveries.
12. The Millionaire Detective – Balance: Unlimited (2020)

- Streaming: Crunchyroll, Funimation
- MAL Score / Episodes: 7.6 / 11
- Studio | Staff: CloverWorks; director Tomohiko Itō
- Plot: A billionaire cop buys outrageous solutions while needling his cash-strapped partner.
- Similarities: Resource-mismatch comedy, duo dynamics, and cases that invert who actually “wins.”
13. Kemono Jihen (2021)

- Streaming: Crunchyroll, Netflix (select regions)
- MAL Score / Episodes: 7.4 / 12
- Studio | Staff: Ajia-do; director Masaya Fujimori
- Plot: Runaway hybrids join a supernatural detective agency to investigate monster crimes.
- Similarities: Underdog children tackling large threats and body-morph “powers” that echo toon physics.
14. Fuuto PI (2022)

- Streaming: Crunchyroll
- MAL Score / Episodes: 7.3 / 12
- Studio | Staff: Studio KAI; sequel to Kamen Rider W
- Plot: Private eye Shotaro and AI partner Phillip use Gaia Memories to stop Dopant crimes in retro-noir Fuuto City.
- Similarities: Gadget-based power system, comedic detective foils, and weekly cases with over-the-top villains.
15. Ron Kamonohashi: Deranged Detective (2023)

- Streaming: Crunchyroll
- MAL Score / Episodes: 7.2 / 13 (S1)
- Studio | Staff: Diomedéa; based on Akira Amano manga
- Plot: A disgraced genius teams with a bumbling cop; together they crack murders despite Ron’s unhinged methods.
- Similarities: Predator-prey verbal sparring, frequent gag reversals, and a case-of-the-week rhythm that leaves status quo intact.
Why These Anime Work for Mentioned Anime Fans
Each pick mirrors The Sylvester & Tweety Mysteries in at least one key way—be it an endlessly sparring duo, a rules-driven “power” gimmick, or mysteries that gleefully pull the rug from under both heroes and viewers. They prove that the charm of watching unlikely partners out-wit villains (and one another) is alive well beyond Looney Tunes’ borders—and that some of anime’s most inventive sleuthing hides just under the radar.